Rosen Y, Moon S, Huang C T, Gourin A, Lyons H A
Arch Pathol Lab Med. 1977 Apr;101(4):170-4.
The occurrence and morphologic aspects of granulomatous pulmonary angiitis were evaluated in open lung biopsy specimens from 128 patients with sarcoidosis. All of the specimens showed parenchymal granulomas characteristic of sarcoidosis, and in 88(69%), granulomatous angiitis was seen. In the speclimens that exhibited granulomatous angiitis, venous involvement was mos common, seen in 92% of the cases. In 61% of these biopsy specimens, only venous involvement was seen; in 31%, both venous and arterial involvement was present. Only 8% of the positive specimens showed arterial lesions exclusively. The extent of angiitis was quantitated. Focal segmental elastic tissue destruction, partial or complete, was a common finding. No instances of aneurysm formation, endothelial erosion, or thrombosis were observed. Occlusive narrowing of small vessels was frequent. Bronchial blood vessels were not involved.
对128例结节病患者的开胸肺活检标本进行了肉芽肿性肺血管炎的发生率及形态学评估。所有标本均显示结节病特征性的实质肉芽肿，88例（69%）可见肉芽肿性血管炎。在出现肉芽肿性血管炎的标本中，静脉受累最为常见，92%的病例可见。在这些活检标本中，61%仅见静脉受累；31%同时存在静脉和动脉受累。仅8%的阳性标本仅显示动脉病变。对血管炎的程度进行了定量。局灶节段性弹性组织部分或完全破坏是常见表现。未观察到动脉瘤形成、内皮侵蚀或血栓形成的情况。小血管闭塞性狭窄很常见。支气管血管未受累。
