淋巴细胞中的受体移动性与受体-细胞质相互作用
Receptor mobility and receptor-cytoplasmic interactions in lymphocytes.
作者信息
Edelman G M, Yahara I, Wang J L
出版信息
Proc Natl Acad Sci U S A. 1973 May;70(5):1442-6. doi: 10.1073/pnas.70.5.1442.
Abstract
An analysis of the inhibition by concanavalin A of the mobility of lymphocyte surface receptors is used to construct an hypothesis on membrane receptor-cytoplasmic interactions. It is proposed that binding of multivalent lectins alters the interaction of an assembly of colchicine-binding proteins with lectin receptors and other receptors, and reciprocally that the state of the colchicine-binding assembly alters the mobility and distribution of surface receptors on the cell membrane. Observations of the effect of colchicine and related drugs on the inhibition of receptor mobility by concanavalin A lend support to this hypothesis. The proposed model has several implications for studies of the initial events of mitogenesis in lymphocytes as well as for cell-cell interactions in general.
摘要
利用伴刀豆球蛋白A对淋巴细胞表面受体流动性的抑制作用进行分析，以构建一个关于膜受体 - 细胞质相互作用的假说。提出多价凝集素的结合改变了秋水仙碱结合蛋白组装体与凝集素受体及其他受体的相互作用，反之，秋水仙碱结合组装体的状态改变了细胞膜上表面受体的流动性和分布。关于秋水仙碱及相关药物对伴刀豆球蛋白A抑制受体流动性的影响的观察结果支持了这一假说。所提出的模型对淋巴细胞有丝分裂起始事件的研究以及一般的细胞 - 细胞相互作用研究有若干启示。
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