Silveira E Souza Adriana Maria Mariano, Mazucato Vivian Marino, Jamur Maria Célia, Oliver Constance
Departamento de Biologia Celular e Molecular e Biagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes, 3900, 14049-900 Ribeirão Preto, Brazil.
J Lipids. 2011;2011:752906. doi: 10.1155/2011/752906. Epub 2011 Feb 10.
Mast cells have long been recognized to have a direct and critical role in allergic and inflammatory reactions. In allergic diseases, these cells exert both local and systemic responses, including allergic rhinitis and anaphylaxis. Mast cell mediators are also related to many chronic inflammatory conditions. Besides the roles in pathological conditions, the biological functions of mast cells include roles in innate immunity, involvement in host defense mechanisms against parasites, immunomodulation of the immune system, tissue repair, and angiogenesis. Despite their growing significance in physiological and pathological conditions, much still remains to be learned about mast cell biology. This paper presents evidence that lipid rafts or raft components modulate many of the biological processes in mast cells, such as degranulation and endocytosis, play a role in mast cell development and recruitment, and contribute to the overall preservation of mast cell structure and organization.
长期以来，肥大细胞在过敏和炎症反应中一直被认为具有直接且关键的作用。在过敏性疾病中，这些细胞会引发局部和全身反应，包括过敏性鼻炎和过敏反应。肥大细胞介质也与许多慢性炎症状况相关。除了在病理状况中的作用外，肥大细胞的生物学功能还包括在固有免疫中的作用、参与针对寄生虫的宿主防御机制、免疫系统的免疫调节、组织修复以及血管生成。尽管它们在生理和病理状况中的重要性日益凸显，但关于肥大细胞生物学仍有许多有待了解之处。本文提供的证据表明，脂筏或筏成分调节肥大细胞中的许多生物学过程，如脱颗粒和内吞作用，在肥大细胞的发育和募集过程中发挥作用，并有助于维持肥大细胞的整体结构和组织。
