估计群体中增殖细胞的比例。
Estimating the proportion of proliferating cells in a population.
作者信息
Appleton D R, Sunter J P
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Dec;32(1):69-73. doi: 10.1007/BF02889014.
In a population of cells that proportion which is actively engaged in the proliferative cycle is often estimated from the ratio of the observed labelling index to an expected labelling index, calculated, on the basis of all cells being in cycle, from the cell cycle phase durations and the age distribution. Ignoring the variability in cell cycle times may lead to large overestimates or underestimates in the expected labelling index. A method is given of obtaining a more accurate estimate of this variable, and hence of the proliferative proportion.
在一群细胞中，通常根据观察到的标记指数与预期标记指数的比值来估计积极参与增殖周期的细胞比例。预期标记指数是基于所有细胞都处于周期中，根据细胞周期阶段持续时间和年龄分布计算得出的。忽略细胞周期时间的变异性可能会导致预期标记指数出现大幅高估或低估。本文给出了一种方法，可更准确地估计这一变量，从而更准确地估计增殖比例。
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