Kromer L F, Bjorklund A, Stenevi U
Science. 1979 Jun 8;204(4397):1117-9. doi: 10.1126/science.451560.
Implants of embryonic neural tissue from all regions of the neuraxis survive grafting to the brains of adult rats. After implantation, neurogenesis and differentiation continue, and connections are formed with the mature host brain. Thus, the intracephalic implants provide excellent model systems for studying cellular interactions that regulate synaptogenesis and determine the cytoarchitectonic organization of developing neural tissues.
来自神经轴所有区域的胚胎神经组织植入物移植到成年大鼠大脑后能够存活。植入后,神经发生和分化继续进行,并与成熟的宿主大脑形成连接。因此,脑内植入物为研究调节突触形成并决定发育中神经组织细胞结构组织的细胞间相互作用提供了极佳的模型系统。