源自电鳗器官和肾膜的钠选择性离子载体材料。
NA + -selective ionophoric material derived from electric organ and kidney membranes.
作者信息
Shamoo A E, Albers R W
出版信息
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1191-4. doi: 10.1073/pnas.70.4.1191.
Abstract
Material that increases black lipid-membrane (oxidized cholesterol) conductance has been demonstrated in the acid-soluble fraction of tryptic digests of membrane fractions from Electrophorus electric organ and beef kidney. The conductance change elicited by this material is highly selective for Na(+). The activity of the material was greatly enhanced by passage through DEAE-cellulose. Activity could be destroyed by further incubation with Pronase. Since conductivity increases exponentially with dose of ionophore, the conductive unit may be an oligomer.
摘要
在电鳗电器官和牛肾的膜组分胰蛋白酶消化产物的酸溶性部分中，已证实存在能增加黑色脂质膜（氧化胆固醇）电导率的物质。该物质引发的电导率变化对Na(+)具有高度选择性。通过DEAE - 纤维素柱后，该物质的活性大大增强。用链霉蛋白酶进一步孵育可破坏其活性。由于电导率随离子载体剂量呈指数增加，导电单位可能是一种寡聚物。
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