细胞会进行周期循环吗？
Do cells cycle?
作者信息
Smith J A, Martin L
出版信息
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1263-7. doi: 10.1073/pnas.70.4.1263.
Abstract
We propose that a cell's life is divided into two fundamentally different parts. Some time after mitosis all cells enter a state (A) in which their activity is not directed towards replication. A cell may remain in the A-state for any lenght of time, throughout which its probability of leaving A-state remains constant. On leaving A-state, cells enter B-phase in which their activities are deterministic, and directed towards replication. Initiation of cell replication processes is thus random, in the sense that radioactive decay is random. Cell population growth rates are determined by the probability with which cells leave the A-state, the duration of the B-phase, and the rate of cell death. Knowledge of these parameters permits precise calculation of the distribution of intermitotic times within populations, the behavior of synchronized cell cultures, and the shape of labeled mitosis curves.
摘要
我们提出，细胞的生命分为两个根本不同的部分。有丝分裂后的一段时间，所有细胞进入一种状态（A），在此状态下它们的活动并非指向复制。一个细胞可以在A状态下停留任意时长，在此期间其离开A状态的概率保持恒定。离开A状态后，细胞进入B期，在此期间它们的活动是确定性的，且指向复制。因此，细胞复制过程的启动是随机的，如同放射性衰变是随机的一样。细胞群体生长速率由细胞离开A状态的概率、B期的持续时间以及细胞死亡率决定。了解这些参数有助于精确计算群体中间期时间的分布、同步化细胞培养物的行为以及标记有丝分裂曲线的形状。
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