Morrison J H, Molliver M E, Grzanna R
Science. 1979 Jul 20;205(4403):313-6. doi: 10.1126/science.451605.
The trajectory of the intracortical noradrenergic fibers has been characterized by histochemical analysis following the production of cortical lesions in the rate. A large group of noradrenergic fibers enters the cortex at the frontal pole and proceeds caudally through the deep layers of dorsolateral cortex. Branches arise from these longitudinally directed fibers and form a uniform pattern of innervation throughout lateral cortex. Because these fibers travel long distances rostrocaudally within the gray matter, a large area of cortex can be deprived of noradrenergic innervation by a relatively small lesion of frontal cortex. The medial and lateral cortex can be selectively and differentially denervated of noradrenergic fibers, and there is a medial to lateral topographic relationship between deep longitudinally running fibers and overlying cortex.
通过对大鼠皮层损伤后的组织化学分析，已对皮层内去甲肾上腺素能纤维的轨迹进行了表征。一大群去甲肾上腺素能纤维在额叶极进入皮层，并通过背外侧皮层的深层向尾侧延伸。分支从这些纵向纤维发出，在整个外侧皮层形成均匀的神经支配模式。由于这些纤维在灰质内沿头尾方向长距离走行，相对较小的额叶皮层损伤就可使大片皮层失去去甲肾上腺素能神经支配。内侧和外侧皮层的去甲肾上腺素能纤维可被选择性地、差异性地去神经支配，并且在深层纵向走行的纤维与上方皮层之间存在从内侧到外侧的拓扑关系。
