Mufson E J, Pandya D N
J Comp Neurol. 1984 May 1;225(1):31-43. doi: 10.1002/cne.902250105.
The course and composition of the cingulum bundle was examined by using the autoradiographic tracer technique in the rhesus monkey. The cingulum bundle is observed to consist of three major fiber components originating from thalamus, cingulate gyrus, and cortical association areas. Following isotope injections in the anterior and lateral dorsal thalamic nuclei, labelled fibers form an arch in the white matter behind the cingulate sulcus and occupy the ventral sector of the cingulum bundle. The fibers from the anterior thalamic nucleus coursing in the cingulum bundle extended rostrally to the frontal cortex and caudally to area 23 and the retrosplenial cortex. In contrast, the fibers from lateral dorsal nucleus reached the retrosplenial cortex as well as the parahippocampal gyrus and presubiculum. Efferent fibers from the cingulate gyrus occupy a dorsolateral sector of the cingulum bundle. Those fibers from area 24 of the cingulate gyrus are directed to the premotor and prefrontal regions as well as area 23 and retrosplenial cortex. The fibers from area 23 extend rostrally to the prefrontal cortex and caudoventrally to the presubiculum and parahippocampal gyrus. Finally, an association component originates mainly from prefrontal cortex and posterior parietal region. These fibers occupy a more dorsal and lateral periphery in the cingulate white matter. Cingulum bundle fibers from the prefrontal cortex extend up to the retrosplenial cortex while those from the posterior parietal cortex extend caudally to the parahippocampal gyrus and presubiculum, and rostrally up to the prefrontal cortex.
采用放射自显影示踪技术在恒河猴中研究了扣带束的走行和组成。观察到扣带束由起源于丘脑、扣带回和皮质联合区的三个主要纤维成分组成。在前背侧丘脑核和外侧背侧丘脑核注射同位素后，标记纤维在扣带沟后方的白质中形成一个弓形，并占据扣带束的腹侧部分。来自丘脑前核并走行于扣带束的纤维向前延伸至额叶皮质，向后延伸至23区和压后皮质。相比之下，来自外侧背核的纤维到达压后皮质以及海马旁回和前扣带。来自扣带回的传出纤维占据扣带束的背外侧部分。来自扣带回24区的那些纤维指向运动前区和前额叶区域以及23区和压后皮质。来自23区的纤维向前延伸至前额叶皮质，向后腹侧延伸至前扣带和海马旁回。最后，一个联合成分主要起源于前额叶皮质和顶叶后部区域。这些纤维在扣带白质中占据更靠背侧和外侧的周边。来自前额叶皮质的扣带束纤维向上延伸至压后皮质，而来自顶叶后部皮质的纤维向后延伸至海马旁回和前扣带，并向前延伸至前额叶皮质。
