紫蛞蝓菌细胞发育阶段的遗传分析。
Genetic analysis of developmental stages of the cellular slime mold Dictyostelium purpureum.
作者信息
Yamada T, Yanagisawa K O, Ono H, Yanagisawa K
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2003-5. doi: 10.1073/pnas.70.7.2003.
71 Mutants of Dictyostelium purpureum, unable to carry out normal development, were isolated. These mutants fall into three phenotypic classes. The mutants of the first class do not aggregate. Those of the second class develop a little further and form conical aggregates. The mutants of the third class progress still further, and the conical aggregates are transformed into finger-shaped masses, but no fruiting bodies are formed. Mutants of each class were able to form fruiting bodies when mixed with mutants of other classes. Pairs of mutants belonging to the same class, however, never responded synergistically. This result indicates the presence of three distinct developmental stages in the process of the fruiting-body formation. Experiments with actinomycin D suggested that genes controlling the developmental process of D. purpureum were divided into three groups which were identical to those identified by the analysis of synergism.
分离出了71株不能进行正常发育的紫盘基网柄菌突变体。这些突变体分为三个表型类别。第一类突变体不聚集。第二类突变体进一步发育并形成锥形聚集体。第三类突变体发育更进一步，锥形聚集体转变为指状团块，但不形成子实体。当与其他类别的突变体混合时，每个类别的突变体都能够形成子实体。然而，属于同一类别的突变体对从未产生协同反应。这一结果表明在子实体形成过程中存在三个不同的发育阶段。用放线菌素D进行的实验表明，控制紫盘基网柄菌发育过程的基因分为三组，这与通过协同作用分析确定的组相同。
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