利福霉素衍生物对人白血病淋巴细胞RNA聚合酶的作用
Action of rifamycin derivatives on RNA polymerase of human leukemic lymphocytes.
作者信息
Tsai M J, Saunders G F
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2072-6. doi: 10.1073/pnas.70.7.2072.
Abstract
The mechanism of inhibition of human RNA polymerase by four rifamycin derivatives was investigated. Derivative AF/013 (3-formyl rifamycin SV:O-n-octyloxime) with strong hydrophobic side chains prevents the polymerase from binding to DNA and also affects the size of RNA synthesized. Derivative PR/19 (3'-acetyl-1'-benzyl-2'-methylpyrrolo[3,2-c]-4-desoxy-rifamycin SV) only affects RNA synthesis when RNA polymerase has been previously incubated with the drug or when the reaction was performed at high salt concentration [0.14 M (NH(4))(2)-SO(4)]. Our results suggest that these drugs exert their inhibitory actions by binding to the enzyme instead of DNA.
摘要
研究了四种利福霉素衍生物对人RNA聚合酶的抑制机制。具有强疏水侧链的衍生物AF/013（3-甲酰基利福霉素SV：O-正辛基肟）可阻止聚合酶与DNA结合，并且还会影响合成的RNA的大小。衍生物PR/19（3'-乙酰基-1'-苄基-2'-甲基吡咯并[3,2-c]-4-脱氧-利福霉素SV）仅在RNA聚合酶预先与该药物孵育时或在高盐浓度[0.14 M硫酸铵]下进行反应时才影响RNA合成。我们的结果表明，这些药物通过与酶而非DNA结合来发挥其抑制作用。
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本文引用的文献
1
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J Mol Biol. 1966 Dec 28;22(2):199-209. doi: 10.1016/0022-2836(66)90126-4.
2
Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.真核生物中DNA依赖性RNA聚合酶的多种形式。
Nature. 1969 Oct 18;224(5216):234-7. doi: 10.1038/224234a0.
3
Base specificity in the interaction of polynucleotides with antibiotic drugs.多核苷酸与抗生素药物相互作用中的碱基特异性。
Science. 1965 Sep 10;149(3689):1259-63. doi: 10.1126/science.149.3689.1259.
4
Molecular structures of DNA-dependent RNA polymerases (II) from calf thymus and rat liver.来自小牛胸腺和大鼠肝脏的DNA依赖性RNA聚合酶（II）的分子结构。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2994-9. doi: 10.1073/pnas.68.12.2994.
5
Transcription of mammalian chromatin by mammalian DNA-dependent RNA polymerases.哺乳动物依赖DNA的RNA聚合酶对哺乳动物染色质的转录。
Eur J Biochem. 1971 Nov 11;23(2):229-41. doi: 10.1111/j.1432-1033.1971.tb01613.x.
6
Actions of the rifamycins.利福霉素的作用。
Bacteriol Rev. 1971 Sep;35(3):290-309. doi: 10.1128/br.35.3.290-309.1971.
7
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Annu Rev Biochem. 1971;40:711-40. doi: 10.1146/annurev.bi.40.070171.003431.
8
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin.α-鹅膏蕈碱对核RNA聚合酶II的特异性抑制作用。
Science. 1970 Oct 23;170(3956):447-9. doi: 10.1126/science.170.3956.447.
9
Inhibition of DNA-dependent RNA synthesis by rifamycins.利福霉素对依赖DNA的RNA合成的抑制作用。
J Antibiot (Tokyo). 1968 Mar;21(3):234-6. doi: 10.7164/antibiotics.21.234.
10
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