McMillian R, Medoff G, Schlessinger D, Kobayashi G S
Sabouraudia. 1977 Nov;15(3):257-61.
Various derivatives of rifamycin were shown to inhibit the RNA polymerases of the yeast and mycelial phases of Histoplasma capsulatum. The relative potency of each of the derivatives against the isolated polymerases was the same as the potency of each against the viable organism. RNA polymerase PC III from the yeast phase was more susceptible to the rifamycin derivatives than yeast phase polymerases PC I and PC II and the biggest differences in susceptibility were seen with the derivative AF/ABDP (2,6-dimethyl-4-benzyl-4-demethyl-rifamycin). The susceptibility pattern of the mycelial polymerase activity was identical to the yeast polymerase PC III.
已证明利福霉素的各种衍生物可抑制荚膜组织胞浆菌酵母期和菌丝体期的RNA聚合酶。每种衍生物对分离出的聚合酶的相对效力与每种对活生物体的效力相同。酵母期的RNA聚合酶PC III比利福平衍生物更易受利福霉素衍生物的影响，而酵母期的聚合酶PC I和PC II则不然，并且在衍生物AF/ABDP（2,6-二甲基-4-苄基-4-去甲基利福霉素）中观察到了最大的敏感性差异。菌丝体聚合酶活性的敏感性模式与酵母聚合酶PC III相同。
