甲状腺激素对小鼠听源性惊厥易感性的影响。
Thyroid hormone influence on the susceptibility of mice to audiogenic seizures.
作者信息
Seyfried T N, Glaser G H, Yu R K
出版信息
Science. 1979 Aug 10;205(4406):598-600. doi: 10.1126/science.451624.
PMID:451624
Abstract
Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.
摘要
在出生后早期，听源性癫痫易感的DBA/2J小鼠的血清甲状腺素水平峰值出现得更早，且显著高于癫痫抗性C57BL/6J小鼠。给予抗甲状腺药物或进行甲状腺切除可抑制DBA/2J小鼠的癫痫易感性，而用过量甲状腺素治疗可增强C57BL/6J小鼠的癫痫易感性。
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