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吗啡对去大脑脊髓猫节段反射的作用。

Actions of morphine on the segmental reflex of the decerebrate-spinal cat.

作者信息

Krivoy W, Kroeger D, Zimmermann E

出版信息

Br J Pharmacol. 1973 Mar;47(3):457-64. doi: 10.1111/j.1476-5381.1973.tb08177.x.

Abstract
  1. The actions of morphine were studied on the segmental reflex of the decerebrate-spinal cat. Morphine decreased arterial blood pressure.2. Morphine inhibited mono- and polysynaptic reflexes. The influence of morphine on monosynaptic reflexes was more obvious at stimulation of the dorsal root at a frequency of 12.5 Hz than at 0.5 or 2.5 Hz.3. The total amount of activity recorded from the ventral root after morphine depended on whether or not the evoked reflex was maximal or submaximal.4. These actions of morphine were antagonized by naloxone.
摘要
  1. 研究了吗啡对去大脑脊髓猫节段反射的作用。吗啡可降低动脉血压。

  2. 吗啡抑制单突触和多突触反射。在以12.5Hz频率刺激背根时,吗啡对单突触反射的影响比在0.5Hz或2.5Hz时更明显。

  3. 吗啡作用后从腹根记录到的总活动量取决于诱发反射是否为最大或次最大反射。

  4. 纳洛酮可拮抗吗啡的这些作用。

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本文引用的文献

1
THE EFFECT OF MORPHINE ON THE DISCHARGE OF MUSCLE SPINDLES WITH INTACT MOTOR INNERVATION.
Int J Neuropharmacol. 1965 May;4:177-83. doi: 10.1016/0028-3908(65)90007-9.
4
Influence of asphyxia on membrane potential level and action potentials of spinal motoand interneurons.
Acta Physiol Scand. 1959 Jan 30;45(1):1-18. doi: 10.1111/j.1748-1716.1959.tb01673.x.
6
Actions of chlorpromazine and of reserpine on spinal reflex activity in the cat.
Proc Soc Exp Biol Med. 1957 Oct;96(1):18-20. doi: 10.3181/00379727-96-23383.

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