Matsumiya T, Sawa A, Ishizuka Y, Oka T
Tokai J Exp Clin Med. 1984 Mar;9(1):13-20.
The electrophysiological effects of morphine, naloxone and capsaicin were studied on c fiber reflex and heat evoked discharge in adult spinal cats. C fiber reflex was recorded from the L7 Ventral root at the time of superficial peroneal nerve electric stimulation. Heat evoked discharge was recorded from the L7 ventral root at the time of hind paw heating. The drugs were injected slowly into the right cephalic vein. Our results can be summarized as follows: morphine depressed the excitatory neuronal activity of capsaicin; morphine followed by capsaicin was antagonized by 0.4 mg/Kg of naloxone; at the c fiber reflex, 2 mg/Kg of morphine depressed the neuronal activity; and at heat evoked discharge, 4 mg/Kg of morphine depressed the neuronal activity. These findings suggest that morphine depressed the effect of capsaicin and this effect was antagonized by naloxone. At the c fiber reflex, morphine was more sensitive than at heat evoked discharge.
研究了吗啡、纳洛酮和辣椒素对成年脊髓猫的C纤维反射和热诱发放电的电生理效应。在腓浅神经电刺激时，从L7腹根记录C纤维反射。在后爪加热时，从L7腹根记录热诱发放电。将药物缓慢注入右侧头静脉。我们的结果总结如下：吗啡抑制辣椒素的兴奋性神经元活动；0.4mg/Kg的纳洛酮可拮抗先注射吗啡后注射辣椒素的作用；在C纤维反射中，2mg/Kg的吗啡抑制神经元活动；在热诱发放电中，4mg/Kg的吗啡抑制神经元活动。这些发现表明，吗啡抑制辣椒素的作用，且这种作用可被纳洛酮拮抗。在C纤维反射中，吗啡比在热诱发放电中更敏感。
