Saito K, Abe K, Ito T, Irokawa N, Otsuka Y, Kusaka T, Yasujima M, Imai Y, Sakurai Y, Chiba S, Ritsu K, Sato M, Haruyama T, Omata K, Yoshinaga K
Tohoku J Exp Med. 1979 May;128(1):13-8. doi: 10.1620/tjem.128.13.
The time courses of change in renin activity after cold storage of human plasma at -5 degrees C and pH 7.4 were examined in 5 normal subjects, 6 patients with essential hypertension and one female patient with primary aldosteronism before and after extirpation of the adrenal tumor. In the 5 normal subjects and 6 essential hypertensives, the gradual increase in plasma renin activity was observed until 10 days of cold storage. The same result was obtained in the case of primary aldosteronism. However, there was no increase in renin activity despite of cold storage for 10 days in plasma which was sampled from this patient 45 days after operation. These data indicate that a period of 4 days for cryoactivation of human plasma renin as has been reported by Sealey et al. is not sufficient to accomplish activation of renin by cold storage.
在5名正常受试者、6名原发性高血压患者以及1名肾上腺肿瘤切除术前和术后的原发性醛固酮增多症女性患者中，研究了人血浆在-5℃和pH 7.4条件下冷藏后肾素活性的变化时间过程。在5名正常受试者和6名原发性高血压患者中，观察到血浆肾素活性在冷藏10天前逐渐增加。原发性醛固酮增多症患者也得到了相同的结果。然而，在该患者术后45天采集的血浆中，尽管冷藏了10天，肾素活性并未增加。这些数据表明，如Sealey等人所报道的，人血浆肾素冷冻激活4天的时间不足以通过冷藏实现肾素的激活。
