Michailov M C, Elsässer E, Welscher U E
Strahlentherapie. 1979 Apr;155(4):284-6.
The mechanical activity (isotonic registration) of isolated detrusor (smooth) muscle preparations from the human urinary bladder (surgical material) is investigated. The preparations reacted on X-irradiation (50 kV) with an immediate dose-dependent tonic contraction at threshold-doses of 100 to 1000 R (1 to 3 kR/min). The contraction was either reversible, semireversible or persistent, and the basal muscle tone was elevated. A tachyphylactic reaction was observed. The phasic activity of the preparations was temporarily increased, then inhibited after irradiation. The radiation-induced changes of the human and guinea-pig detrusor muscle are compared and their possible relation to the functional disturbances of the urinary bladder after radiotherapy is discussed.
对取自人膀胱（手术材料）的离体逼尿肌（平滑肌）制剂的机械活性（等张记录）进行了研究。这些制剂在接受X射线照射（50 kV）时，在100至1000 R的阈剂量（1至3 kR/分钟）下会立即出现剂量依赖性的强直性收缩。收缩反应要么是可逆的、半可逆的，要么是持续性的，并且基础肌张力升高。观察到快速耐受性反应。制剂的相性活动先暂时增强，然后在照射后受到抑制。比较了人和豚鼠逼尿肌的辐射诱导变化，并讨论了它们与放疗后膀胱功能障碍的可能关系。
