Michailov M C, Prechter I, Greimel H, Welscher U E
Strahlentherapie. 1983 Jul;159(7):448-51.
The action of X-rays (50 kV, filtered by 0.3 mm Al) on helical strip of frog aorta (rana esculenta) has been investigated. The isolated preparations have a stable basal tone and are radio-sensitive to X-rays which induce reversible, dose-dependent, contractile responses. After repeated irradiation tachyphylaxis appears. The threshold doses are about 250 Rat 3 to 6 kR/min, antiadrenergic (phentolamine, propranolol), anticholinergic (atropin), antihistaminic (Neo-Bridal) and serotoninergic (Deseril) drugs have no visible influence on the X-ray induced reaction, i.e. these action mechanisms of the irradiation-induced contraction do not seem probable. Theophylline and cAMP inhibit the X-ray contraction probably non-specifically. Indometacin also inhibits the X-ray contraction: this suggests participation of prostaglandin-mechanism on the contraction of frog aorta after irradiation.
研究了X射线（50千伏，经0.3毫米铝过滤）对青蛙（食用蛙）主动脉螺旋条的作用。分离出的标本具有稳定的基础张力，对X射线具有放射敏感性，X射线可诱导可逆的、剂量依赖性的收缩反应。反复照射后会出现快速耐受性。阈剂量约为250拉德3至6千伦琴/分钟，抗肾上腺素能药物（酚妥拉明、普萘洛尔）、抗胆碱能药物（阿托品）、抗组胺药物（新安替根）和5-羟色胺能药物（地昔帕明）对X射线诱导的反应没有明显影响，即这些辐射诱导收缩的作用机制似乎不太可能。茶碱和环磷酸腺苷可能非特异性地抑制X射线收缩。吲哚美辛也抑制X射线收缩：这表明前列腺素机制参与了照射后青蛙主动脉的收缩。
