Minette A, Marcq M
Rev Inst Hyg Mines (Hasselt). 1979;34(3):115-23.
The changes in FEV1 and in specific conductance induced by 200 micrograms oxitropium bromide given as pressurized aerosol were measured at 8 time intervals during 7 hours after inhalation in a group of 19 patients with reversible broncho-obstruction. The working of the drug was compared to the functional values observed at the same time intervals after placebo, 40 micrograms ipratropium bromide and 400 micrograms fenoterol. Both oxitropium and ipratropium were definitely and significantly superior to placebo at all time intervals. Oxitropium was superior to ipratropium at the 7th hour. At this time interval the difference was significant At the 7th hour oxitropium gave higher mean results than fenoterol, but this difference was not significant. The drug was also compared to its competitors regarding its subjective and cardiovascular tolerance. No unfavourable side-effects were observed.
在一组19例可逆性支气管阻塞患者中，于吸入200微克溴化氧托品（以压力定量气雾剂给药）后的7小时内，每隔一定时间间隔测量1秒用力呼气容积（FEV1）和比气道传导率的变化。将该药的作用与安慰剂、40微克异丙托溴铵和400微克非诺特罗在相同时间间隔后观察到的功能值进行比较。在所有时间间隔，氧托品和异丙托溴铵均明显且显著优于安慰剂。在第7小时，氧托品优于异丙托溴铵。在此时间间隔，差异具有显著性。在第7小时，氧托品的平均结果高于非诺特罗，但这种差异不具有显著性。还就该药的主观耐受性和心血管耐受性与其他同类药物进行了比较。未观察到不良副作用。
