Bondarenko T I, Makletsova M G
Ukr Biokhim Zh (1978). 1979 Mar-Apr;51(2):135-8.
The content of homocarnosine, gamma-amino butyric acid and histidine was studied in the brain of newborn, 1, 7, 14, 21 and 30-day rabbits in normalcy and under hyperoxia. For 30 days of the postnatal life the amount of peptide in the animal brain is 2.5, histidine 1.6, gamma-amino butyric acid--2.2 times as high. At the preconvulsive stage of oxygen poisoning the content of homocarnosine lowers sharply in the brain of rabbits of all age groups. The most considerable decrease is observed in the brain of 14, 21 and 30-day rabbits by 53, 60 and 85%, respectively. The content of gamma-amino butyric acid lowers only in the brain of 21 and 30-day animals by 39 and 47%, respectively; the content of histidine in these animals under hyperoxia, vice versa, increases by 10 and 25%.
研究了正常和高氧条件下新生、1日龄、7日龄、14日龄、21日龄和30日龄家兔大脑中高肌肽、γ-氨基丁酸和组氨酸的含量。在出生后30天的生命期内，动物大脑中肽的含量是2.5倍，组氨酸是1.6倍，γ-氨基丁酸是2.2倍。在氧中毒的惊厥前期，所有年龄组家兔大脑中高肌肽的含量均急剧下降。在14日龄、21日龄和30日龄家兔的大脑中观察到最显著的下降，分别下降了53%、60%和85%。γ-氨基丁酸的含量仅在21日龄和30日龄动物的大脑中分别下降了39%和47%；在高氧条件下，这些动物大脑中组氨酸的含量则分别增加了10%和25%。
