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[Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia].

作者信息

Bondarenko T I, Krichevskaia A A, Shugaleĭ V S

出版信息

Ukr Biokhim Zh (1978). 1978 Sep-Oct;50(5):573-5.

PMID:726092
Abstract

The content of homocarnosine, GAMA, histidine, glutaminic acid and activity of glutamate decarboxylase were studied in four regions of rats brain: cerebral hemispheres, midbrain, diencephalon and cerebellum, in norm and under hyperoxia. A considerable decrease in the content of homocarnosine, GAMA and histidine is observed in all the studied regions of the rat brain in the convulsion stage of oxygen poisoning. A decrease in the glutamate decarboxylase activity is the reason for a drop in the GAMA content. Homocarnosine in the brain is bound functionally with the GAMA level.

摘要

相似文献

1
[Metabolism of homocarnosine and gamma-amino butyric acid in different regions of rat brain under hyperoxia].
Ukr Biokhim Zh (1978). 1978 Sep-Oct;50(5):573-5.
2
[Content of homocarnosine, gamma-amino butyric acid and histidine in brain tissue of different age normal rabbits and under hyperoxia].[不同年龄正常家兔及高氧状态下家兔脑组织中同型肌肽、γ-氨基丁酸和组氨酸的含量]
Ukr Biokhim Zh (1978). 1979 Mar-Apr;51(2):135-8.
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[Homocarnosine levels in various regions of the rat brain and blood in hypoxia and after hyperbaric oxygenation].[缺氧及高压氧治疗后大鼠脑和血液各区域中高肌肽水平]
Vopr Med Khim. 1985 Jan-Feb;31(1):74-6.
4
[Homocarnosine content and homocarnosine-carnosine synthetase activity in brain areas of hyperoxic rats].
Ukr Biokhim Zh (1978). 1979 Sep-Oct;51(5):483-6.
5
[Homocarnosine levels in repeated hypothermia and hibernation].
Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):72-5.
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[Effect of hyperbaric oxygenation on homocarnosine metabolism in the brains of rabbits of different ages].
Vopr Med Khim. 1982 Mar-Apr;28(2):125-8.
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[Protective effect of the neuropeptide homocarnosine in hyperbaric oxygenation].
Vopr Med Khim. 1985 Jul-Aug;31(4):75-9.
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[Intensity of label incorporation from [1,4-14C]putrescine into homocarnosine in the brain of rats of various ages].
Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):75-7.
9
[Activity of several the mediator systems of the brain during hyperbaric oxygenation].[高压氧疗期间大脑几种介质系统的活性]
Fiziol Zh SSSR Im I M Sechenova. 1979 Aug;65(8):1214-9.
10
Homocarnosinosis: increased content of homocarnosine and deficiency of homocarnosinase in brain.肌肽血症:大脑中肌肽含量增加且肌肽酶缺乏。
J Neurochem. 1979 Jun;32(6):1637-40. doi: 10.1111/j.1471-4159.1979.tb02273.x.

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Rapid decrease of GAD 67 content before the convulsion induced by hyperbaric oxygen exposure.高压氧暴露诱发惊厥前GAD 67含量迅速下降。
Neurochem Res. 2008 Jan;33(1):185-93. doi: 10.1007/s11064-007-9436-4. Epub 2007 Aug 22.