Totskii V N
Ukr Biokhim Zh (1978). 1979 Mar-Apr;51(2):139-46.
The gravitaiton overloading causes in experimental animals a decrease in stability of erythrocytes to NaCl hypotonic solutions and liver mitochondria to the effect of triton X=100. Under these conditions permeability of erythrocytes and leucocytes membranes as well as of the liver and brain mitochondria increases for [14C] nicotinate, [35S] lipoate, riboflavin and flavin mononucleotide, the total activity and the activity of the unprecipitable protinase of the liver cell lysosomas rise. Hydrocortisone, pyruvate, ATP, water- and fatty-soluble vitamins in the in vivo and in vitro experiments weaken the effect of overloading on the stability and permeability of the structures under study. Vitamin E applied separately and in combination with vitamin B, flavin mononucleotide and nicotinamide is more effective in this respect.
重力过载导致实验动物的红细胞对氯化钠低渗溶液的稳定性降低，肝脏线粒体对曲拉通X - 100的作用的稳定性降低。在这些条件下，红细胞和白细胞膜以及肝脏和脑线粒体对[14C]烟酸、[35S]硫辛酸、核黄素和黄素单核苷酸的通透性增加，肝细胞溶酶体的总活性和不可沉淀蛋白酶的活性升高。在体内和体外实验中，氢化可的松、丙酮酸、ATP、水溶性和脂溶性维生素减弱了过载对所研究结构的稳定性和通透性的影响。在这方面，单独使用维生素E以及与维生素B、黄素单核苷酸和烟酰胺联合使用更有效。
