患有慢性粒细胞白血病且具有45,XO,Ph1染色体模式的男性。

Shiffman N J, Stecker E, Conen P E, Gardner H A

Can Med Assoc J. 1974 May 18;110(10):1151-4.

Two cases of chronic myeloid leukemia in which the cytogenetic clone was 45, XO, Ph(1) are described and compared with 20 cases recorded in the literature. The 45, XO line is peculiar to the leukemic cells and is not a manifestation of constitutional mosaicism. It probably arises from a 46, XY, Ph(1) line by loss of the Y chromosome. Because of the few cases reported, one cannot be certain that these men have a better prognosis, although the median survival time suggests that this is so. Infertility is not part of this disorder.

本文描述了两例细胞遗传学克隆为45,XO,Ph(1)的慢性髓性白血病病例，并与文献中记录的20例病例进行了比较。45,XO系是白血病细胞所特有的，并非体质性嵌合体的表现。它可能由46,XY,Ph(1)系通过Y染色体丢失产生。由于报道的病例较少，尽管中位生存时间提示情况如此，但无法确定这些男性患者的预后是否更好。不育并非该疾病的一部分。