伴有D三体的费城染色体阴性慢性髓性白血病
Philadelphia chromosome-negative chronic myelogenous leukemia with trisomy D.
作者信息
Shashaty G G, Baumiller R C
出版信息
Arch Pathol Lab Med. 1980 Jul;104(7):376-8.
PMID:6930938
Abstract
Previous reports emphasize that trisomy 8 is the most common, single chromosomal abnormality in both Philadelphia (Ph1) chromosome-positive and Ph1-negative chronic myelogenous leukemia (CML). Karyotype analysis on a 78-year-old man with Ph1-negative CML showed trisomy D, confirmed on banding studies to be an extra No. 14 chromosome. Although the abnormality is likely to be related to the leukemic clone, the importance of this chromosomal deviation is not known.
摘要
先前的报告强调，8号染色体三体是费城（Ph1）染色体阳性和Ph1阴性慢性粒细胞白血病（CML）中最常见的单一染色体异常。对一名78岁的Ph1阴性CML男性患者进行的核型分析显示有D组染色体三体，经显带研究证实为额外的14号染色体。虽然这种异常可能与白血病克隆有关，但这种染色体偏差的重要性尚不清楚。
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