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1
Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.麦角酸二乙酰胺干扰兔抗体生物合成的机制。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1061-4. doi: 10.1073/pnas.71.4.1061.
2
Comparative inhibitory action of D- and L-tryptophan on the effect of d-lysergic acid diethylamide in vitro.
Mol Pharmacol. 1974 Jan;10(1):68-77.
3
In vitro effect of d-lysergic acid diethylamide on immunoglobulin synthesis.
Biochem Biophys Res Commun. 1973 Feb 5;50(3):950-6. doi: 10.1016/0006-291x(73)91337-5.
4
Incorporation of a lysergic acid diethylamide intermediate into antibody protein in vitro.
Mol Pharmacol. 1973 May;9(3):421-5.
5
Light chain peptide secreted by rabbit antibody producing and murine MOPC 315 myeloma cells in the presence of D-lysergic acid diethylamide (LSD).
Immunochemistry. 1975 Apr;12(4):279-84. doi: 10.1016/0019-2791(75)90176-7.
6
Lysergic acid diethylamide: role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine).麦角酸二乙酰胺：在血浆色氨酸转化为脑血清素（5-羟色胺）中的作用。
Science. 1969 Oct 10;166(3902):237-9. doi: 10.1126/science.166.3902.237.
7
Studies on the mechanism of covalent incorporation of a lysergyl derivative to immunoglobulin peptides in vitro.
J Biol Chem. 1975 Mar 25;250(6):2164-72.
8
Anti-lysergyl antibody: measurement of binding parameters in IgG fractions.抗利血平抗体：IgG 组分中结合参数的测定
Immunochemistry. 1974 Jun;11(6):285-93. doi: 10.1016/0019-2791(74)90364-4.
9
Specificity of the antibody receptor site to D-lysergamide: model of a physiological receptor for lysergic acid diethylamide.抗体受体位点对D-麦角酰胺的特异性：麦角酸二乙酰胺的生理受体模型。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1483-7. doi: 10.1073/pnas.68.7.1483.
10
Antibody isoelectric spectra. Analysis of the heterogeneity of antibody molecules in serum by isoelectric focusing in gel and specific detection with hapten.抗体等电谱。通过凝胶等电聚焦和半抗原特异性检测分析血清中抗体分子的异质性。
Eur J Immunol. 1971 Nov;1(5):390-4. doi: 10.1002/eji.1830010517.

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本文引用的文献

1
The secretion of antibody by isolated lymph node cells.分离的淋巴结细胞分泌抗体。
J Biol Chem. 1961 Feb;236:464-73.
2
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
3
Isoelectric focusing in polyacrylamide gels.聚丙烯酰胺凝胶等电聚焦
Biochim Biophys Acta. 1971 Apr 27;236(1):17-28. doi: 10.1016/0005-2795(71)90144-9.
4
Fluorescein. Hapten and antibody active-site probe.荧光素。半抗原及抗体活性位点探针。
Biochemistry. 1971 Jan 19;10(2):208-13. doi: 10.1021/bi00778a003.
5
Studies of 125I trace labeling of immunoglobulin G by chloramine-T.用氯胺 - T对免疫球蛋白G进行¹²⁵I微量标记的研究。
Immunochemistry. 1970 Nov;7(11):885-98. doi: 10.1016/0019-2791(70)90051-0.
6
Symposium on in vitro studies of the immune response. 3. Biochemical agents affecting the inductive phase of the secondary antibody respose initiated in vitro.免疫反应的体外研究研讨会。3. 影响体外引发的二次抗体反应诱导期的生化试剂。
Bacteriol Rev. 1966 Jun;30(2):408-17. doi: 10.1128/br.30.2.408-417.1966.
7
Differences in spectral properties and tryptophan content among rabbit anti-2,4-dinitrophenyl antibodies of the gamma G-immunologbulin class.γG免疫球蛋白类兔抗2,4-二硝基苯基抗体的光谱特性和色氨酸含量差异。
Biochemistry. 1968 May;7(5):1919-28. doi: 10.1021/bi00845a041.
8
Incorporation of a lysergic acid diethylamide intermediate into antibody protein in vitro.
Mol Pharmacol. 1973 May;9(3):421-5.
9
In vitro effect of d-lysergic acid diethylamide on immunoglobulin synthesis.
Biochem Biophys Res Commun. 1973 Feb 5;50(3):950-6. doi: 10.1016/0006-291x(73)91337-5.
10
Intracellular biosynthesis of rabbit antibody.兔抗体的细胞内生物合成
J Biol Chem. 1967 Oct 10;242(19):4495-500.

麦角酸二乙酰胺干扰兔抗体生物合成的机制。

Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.

作者信息

Voss E W, Winkelhake J L

出版信息

Proc Natl Acad Sci U S A. 1974 Apr;71(4):1061-4. doi: 10.1073/pnas.71.4.1061.

DOI:10.1073/pnas.71.4.1061
PMID:4524614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388162/
Abstract

Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lysergic acid diethylamide secreted only 7S IgG molecules with an average pI of approximately 7.0.

摘要

在存在d - 麦角酸二乙酰胺的情况下孵育的、产生针对半抗原抗体的超免疫兔的淋巴细胞，继续以正常速率合成蛋白质。对与麦角酸二乙酰胺一起孵育的细胞分泌的低分子量蛋白质进行等电聚焦分析，显示有两个组分，其等电点分别为4.9和5.2。未接触麦角酸二乙酰胺的免疫细胞仅分泌平均等电点约为7.0的7S IgG分子。