麦角酸二乙酰胺干扰兔抗体生物合成的机制。
Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.
作者信息
Voss E W, Winkelhake J L
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1061-4. doi: 10.1073/pnas.71.4.1061.
Abstract
Lymphoid cells from hyperimmune rabbits producing antibodies to a hapten, incubated in the presence of d-lysergic acid diethylamide, continued to synthesize protein at a normal rate. Isoelectric focusing analysis of the low-molecular-weight protein secreted by the cells incubated with lysergic acid diethylamide indicated two components, with pI's of 4.9 and 5.2. Immune cells not exposed to lysergic acid diethylamide secreted only 7S IgG molecules with an average pI of approximately 7.0.
摘要
在存在d - 麦角酸二乙酰胺的情况下孵育的、产生针对半抗原抗体的超免疫兔的淋巴细胞，继续以正常速率合成蛋白质。对与麦角酸二乙酰胺一起孵育的细胞分泌的低分子量蛋白质进行等电聚焦分析，显示有两个组分，其等电点分别为4.9和5.2。未接触麦角酸二乙酰胺的免疫细胞仅分泌平均等电点约为7.0的7S IgG分子。
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