阿霉素和柔红霉素对突变型T4 DNA聚合酶的抑制作用。
Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases.
作者信息
Goodman M F, Bessman M J, Bachur N R
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1193-6. doi: 10.1073/pnas.71.4.1193.
Abstract
The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3'-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.
摘要
抗癌药物阿霉素和柔红霉素，以及另外两种DNA试剂溴化乙锭和9-氨基吖啶，对由突变型和野生型噬菌体T4诱导的纯化DNA聚合酶的核苷酸掺入均产生不同的抑制作用。与野生型噬菌体的DNA聚合酶相比，抗突变酶受到的抑制程度要大得多，而突变酶受到的抑制程度较小。相比之下，野生型和突变体的聚合酶相关3'-外切核酸酶活性也受到这些化合物的抑制，但没有差异。
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本文引用的文献
1
[INHIBITION OF DNA-DEPENDENT RNA AND DNA SYNTHESIS BY ANTIBIOTICS].[抗生素对依赖DNA的RNA和DNA合成的抑制作用]
Biochem Z. 1964 Dec 7;341:126-8.
2
ON PHYSICO-CHEMICAL INTERACTIONS BETWEEN DAUNOMYCIN AND NUCLEIC ACIDS.关于柔红霉素与核酸之间的物理化学相互作用
Biochim Biophys Acta. 1965 May 11;103:25-49. doi: 10.1016/0005-2787(65)90539-3.
3
A DEOXYRIBONUCLEASE INDUCED BY INFECTION WITH BACTERIOPHAGE T2.由噬菌体T2感染诱导产生的一种脱氧核糖核酸酶。
J Biol Chem. 1964 Sep;239:2935-43.
4
The interaction of aminocridines with nucleic acids.氨基吖啶与核酸的相互作用。
Biopolymers. 1968;6(9):1225-53. doi: 10.1002/bip.1968.360060902.
5
Comparison of the antileukemic effect in mice of adriamycin (NSC-123127) with daunomycin (NSC-82151).阿霉素（NSC - 123127）与柔红霉素（NSC - 82151）对小鼠抗白血病作用的比较。
Cancer Chemother Rep. 1970 Feb;54(1):1-7.
6
Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation.抗生素和药物结合对闭环DNA中超螺旋的影响：涉及嵌入作用分子模型的证据
J Mol Biol. 1970 Dec 14;54(2):247-79. doi: 10.1016/0022-2836(70)90429-8.
7
Effects of adriamycin on human lymphocytes stimulated with PHA "in vitro".阿霉素对体外经PHA刺激的人淋巴细胞的作用。
Rev Eur Etud Clin Biol. 1970 Aug-Sep;15(7):793-9.
8
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Science. 1965 Sep 10;149(3689):1259-63. doi: 10.1126/science.149.3689.1259.
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