位置信息与位置分化模型
Models for positional information and positional differentiation.
作者信息
Babloyantz A, Hiernaux J
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1530-3. doi: 10.1073/pnas.71.4.1530.
Abstract
It is commonly thought that the formation of patterns in developing organisms is due to the existence of a gradient of a morphogen that determines the fate of cells as a function of position in the organism. A model is presented based on a molecular mechanism where the gradient is established by the active transport of a morphogen between source and sink. The cellular differentiation and the subsequent spatial pattern formation results from the interaction of this morphogen with the genetic regulatory mechanisms of cells. Some properties of the model are given and discussed in relation to grafting experiments in hydra.
摘要
人们普遍认为，发育中的生物体中模式的形成是由于形态发生素梯度的存在，这种梯度根据生物体中细胞的位置决定细胞的命运。本文提出了一个基于分子机制的模型，其中梯度是通过形态发生素在源和汇之间的主动运输建立的。细胞分化以及随后的空间模式形成是这种形态发生素与细胞遗传调控机制相互作用的结果。文中给出了该模型的一些特性，并结合水螅的嫁接实验进行了讨论。
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本文引用的文献
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Chemical instabilities of "all-or-none" type in beta - galactosidase induction and active transport.β-半乳糖苷酶诱导和主动转运中“全或无”型的化学不稳定性
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Regeneration of hydra from reaggregated cells.由重聚集细胞再生水螅。
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Experimental studies on axial polarity in hydra.水螅轴极性的实验研究。
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