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通过生物建模对钾代谢研究结果的评估

[Evaluation of research findings of potassium metabolism through biological modeling].

作者信息

Wüstenberg P W, Neumann J

出版信息

Z Urol Nephrol. 1979 Feb;72(2):107-18.

PMID:452735
Abstract

The cybernetic modelling of the water balance and the electrolyte balance has a heuristic value for the physiology and pathophysiology, by clearing up connections and open problems. This concerns problems of regulation size and regulation extension, but also the validity of reference values. Under this aspect is referred to the significance of steady state, input- and output inbalances and of the static and dynamic characteristics in the examination of the functional performance of the regulation circle. The static and dynamic compartment modelling is discussed at the instance of the potassium balance and exemplarily confirmed by findings of examinations. Here is referred to the special information value of the dynamic compartment analyse, as apart from the pool sizes (capacities) also intracorporal turnover rates (effects) are established.

摘要

通过厘清各种联系和尚未解决的问题,水平衡和电解质平衡的控制论模型对生理学和病理生理学具有启发价值。这涉及调节规模和调节范围的问题,也关乎参考值的有效性。从这方面来看,稳态、输入和输出失衡以及调节回路功能性能检查中的静态和动态特征的意义都被提及。以钾平衡为例讨论了静态和动态区室建模,并通过检查结果进行了示例性验证。这里提到了动态区室分析的特殊信息价值,因为除了库容量(容量)之外,还确定了体内周转率(效应)。

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