Coquin Y, Modai J
Nouv Presse Med. 1979 Jan 6;8(1):23-6.
In spite of extreme and persistent susceptibility to antibiotics, specially benzylpenicillin, the pathology due to pneumococcus remains frequent and serious. From 14 cases of pneumococcal meningitis associated with pneumonia the authors have studied the relationship between these two localizations. They conclude that meningeal seeding appears most frequently secondarily and is probably latent at the beginning. Moreover they note that treatment of pneumonia by itself does not always prevent the occurence of the meningitis. Density of bacterial population, prolunged bacteremia, resistance of pneumococcus to phagocytic mechanisms and the delay of treatment might explain these findings. For those reasons the authors recommend the use of high doses of benzylpenicillin for the treatment of lately diagnosed bacterial pneumonia.
尽管对包括苄青霉素在内的抗生素存在极端且持续的易感性,但肺炎球菌所致的病理情况仍然常见且严重。作者对14例合并肺炎的肺炎球菌性脑膜炎病例进行了研究,以探讨这两种局部感染之间的关系。他们得出结论,脑膜播散最常继发出现,且一开始可能处于潜伏状态。此外,他们指出,仅治疗肺炎并不总能预防脑膜炎的发生。细菌数量密度、持续性菌血症、肺炎球菌对吞噬机制的抗性以及治疗延迟可能解释了这些发现。基于这些原因,作者建议使用高剂量苄青霉素治疗近期诊断的细菌性肺炎。