安莎霉素生物合成：对从地中海诺卡氏菌突变株中分离出的一种新型利福霉素的研究。
Ansamycin biogenesis: studies on a novel rifamycin isolated from a mutant strain of Nocardia mediterranei.
作者信息
White R J, Martinelli E, Lancini G
出版信息
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3260-4. doi: 10.1073/pnas.71.8.3260.
Abstract
A novel ansamycin, rifamycin W, was isolated from a mutant strain of Nocardia mediterranei. The metabolic origin of rifamycin W was studied by (13)C nuclear magnetic resonance spectroscopy. Examination of the proton-decoupled pulse and Fourier transform (13)C spectra of rifamycin W biogenetically enriched with [1-(13)C]-, [2-(13)C]-, and [3-(13)C]propionate and with [1-(13)C]acetate has revealed that the alignment of acetate and propionate units corresponds to that previously proposed for rifamycin S. Washed mycelium from a rifamycin B-producing strain of N. mediterranei transformed rifamycin W into rifamycin B. We suggest that rifamycin W is a normal intermediate in the biosynthesis of the other rifamycins. These results, together with the structural similarity of rifamycin W to the streptovaricins, reinforce our hypothesis that a common progenitor is involved in the biogenesis of all naphthalenic ansamycins.
摘要
从地中海诺卡氏菌的一个突变株中分离出一种新型安莎霉素——利福霉素W。通过碳-13核磁共振光谱研究了利福霉素W的代谢起源。对用[1-(13)C]-、[2-(13)C]-和[3-(13)C]丙酸酯以及[1-(13)C]乙酸酯进行生物合成富集的利福霉素W的质子去耦脉冲和傅里叶变换碳-13光谱的研究表明，乙酸酯和丙酸酯单元的排列与先前对利福霉素S所提出的排列一致。来自地中海诺卡氏菌的一个产利福霉素B菌株的洗涤菌丝体将利福霉素W转化为利福霉素B。我们认为利福霉素W是其他利福霉素生物合成中的正常中间体。这些结果，连同利福霉素W与链黑菌素的结构相似性，强化了我们的假设，即所有萘并安莎霉素的生物合成都涉及一个共同的前体。
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Proc Natl Acad Sci U S A. 1974 Aug;71(8):3260-4. doi: 10.1073/pnas.71.8.3260.
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Streptovaricin. I. Discovery and biologic activity.链黑菌素。一、发现及生物活性。
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2
Geldanamycin, a new antibiotic.格尔德霉素，一种新型抗生素。
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Improved differential spectrophotometric determination of rifamycins.利福霉素改良差示分光光度测定法
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4
A proposal for the transfer of Streptomyces mediterranei Margalith and Beretta 1960 to the genus Nocardia as Nocardia mediterranea (Margalith and Beretta) comb. nov.关于将1960年的地中海链霉菌（Margalith和Beretta）转移至诺卡氏菌属，命名为地中海诺卡氏菌（Nocardia mediterranea）（Margalith和Beretta）新组合的提议
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Isolation of rifamycin SV from a mutant Streptomyces mediterranei strain.从地中海链霉菌突变株中分离利福霉素SV。
J Antibiot (Tokyo). 1969 Dec;22(12):637-8. doi: 10.7164/antibiotics.22.637.
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