安莎霉素生物合成的早期中间体。I. 原利福霉素I的分离与鉴定。
Early intermediates in the biosynthesis of ansamycins. I. Isolation and identification of protorifamycin I.
作者信息
Ghisalba O, Traxler P, Nüesch J
出版信息
J Antibiot (Tokyo). 1978 Nov;31(11):1124-31. doi: 10.7164/antibiotics.31.1124.
PMID:721708
Abstract
A mutant strain derived from Nocardia mediterranei N813 was found to accumulate a number of novel ansamycins structurally related to the protostreptovaricins and to rifamycin W. One of the main components of this ansamycin complex, protorifamycin I (8-deoxyrifamycin W), was purified and identified by means of chemical and spectroscopic methods.
摘要
从地中海诺卡氏菌N813衍生出的一个突变菌株被发现积累了许多与原链黑菌素和利福霉素W结构相关的新型安莎霉素。该安莎霉素复合物的主要成分之一，原利福霉素I（8-脱氧利福霉素W），通过化学和光谱方法进行了纯化和鉴定。
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