聚合物凝胶植入物的扩散
Diffusion of polymer gel implants.
作者信息
Davis B K
出版信息
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3120-3. doi: 10.1073/pnas.71.8.3120.
Abstract
Crosslinked polyacrylamide and polyvinylpyrrolidone gels have been used to subcutaneously implant (125)I-labeled immunoglobulin, (125)I-labeled luteinizing hormone, (125)I-labeled bovine serum albumin, (125)I-labeled insulin, [(3)H]prostaglandin F(2alpha), and Na(125)I into hamsters. From the rates of absorption of the solutes, their diffusion coefficients were determined. The diffusion coefficients showed a logarithmic dependence on implant polymer concentration and solute molecular weight. Release of the solutes from gel preparations incubated 10 mM phosphate buffer (pH 7.2) at 37 degrees revealed a similar relationship between solute diffusion coefficient, molecular weight, and the concentration of polymer. A general equation was derived that gives the expected diffusion coefficient of a substance in a polymer gel from its molecular weight, diffusion coefficient in solvent, and polymer concentration of the gel.
摘要
交联聚丙烯酰胺和聚乙烯吡咯烷酮凝胶已被用于将（125）I标记的免疫球蛋白、（125）I标记的促黄体生成素、（125）I标记的牛血清白蛋白、（125）I标记的胰岛素、[（3）H]前列腺素F（2α）和碘化钠皮下植入仓鼠体内。根据溶质的吸收速率，测定了它们的扩散系数。扩散系数对植入聚合物浓度和溶质分子量呈对数依赖性。在37℃下于10 mM磷酸盐缓冲液（pH 7.2）中孵育的凝胶制剂中溶质的释放显示，溶质扩散系数、分子量和聚合物浓度之间存在类似关系。推导了一个通用方程，该方程可根据物质的分子量、在溶剂中的扩散系数以及凝胶的聚合物浓度，给出其在聚合物凝胶中的预期扩散系数。
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