从软性隐形眼镜和植入物到自组装纳米材料的水凝胶
HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS.
作者信息
Kopeček Jindřich
机构信息
Department of Bioengineering, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
J Polym Sci A Polym Chem. 2009 Nov 15;47(22):5929-5946. doi: 10.1002/pola.23607.
Abstract
Hydrogels were the first biomaterials designed for clinical use. Their discovery and applications as soft contact lenses and implants are presented. This early hydrogel research served as a foundation for the expansion of biomedical polymers research into new directions: design of stimuli sensitive hydrogels that abruptly change their properties upon application of an external stimulus (pH, temperature, solvent, electrical field, biorecognition) and hydrogels as carriers for the delivery of drugs, peptides, and proteins. Finally, pathways to self-assembly of block and graft copolymers into hydrogels of precise 3D structures are introduced.
摘要
水凝胶是最早设计用于临床的生物材料。文中介绍了它们作为软性隐形眼镜和植入物的发现及应用。早期的水凝胶研究为生物医学聚合物研究拓展到新方向奠定了基础：设计对刺激敏感的水凝胶，这类水凝胶在施加外部刺激（pH值、温度、溶剂、电场、生物识别）时会突然改变其性质；以及将水凝胶用作药物、肽和蛋白质递送的载体。最后，介绍了嵌段共聚物和接枝共聚物自组装成具有精确三维结构的水凝胶的途径。
相似文献
1
HYDROGELS FROM SOFT CONTACT LENSES AND IMPLANTS TO SELF-ASSEMBLED NANOMATERIALS.从软性隐形眼镜和植入物到自组装纳米材料的水凝胶
J Polym Sci A Polym Chem. 2009 Nov 15;47(22):5929-5946. doi: 10.1002/pola.23607.
2
In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery.用于药物递送的原位凝胶化刺激敏感型嵌段共聚物水凝胶
J Control Release. 2008 May 8;127(3):189-207. doi: 10.1016/j.jconrel.2008.01.005. Epub 2008 Jan 26.
3
(Macro)molecular self-assembly for hydrogel drug delivery.用于水凝胶药物输送的（宏观）分子自组装。
Adv Drug Deliv Rev. 2021 May;172:275-295. doi: 10.1016/j.addr.2021.01.006. Epub 2021 Jan 12.
4
Synthesis and Characterization of Novel pH-Responsive Aminated Alginate Derivatives Hydrogels for Tissue Engineering and Drug Delivery.用于组织工程和药物递送的新型pH响应性胺化海藻酸盐衍生物水凝胶的合成与表征
Curr Org Synth. 2023 Nov 3. doi: 10.2174/0115701794210967231016055949.
5
Self-Assemblable Polymer Smart-Blocks for Temperature-Induced Injectable Hydrogel in Biomedical Applications.用于生物医学应用中温度诱导可注射水凝胶的自组装聚合物智能块
Front Chem. 2020 Jan 31;8:19. doi: 10.3389/fchem.2020.00019. eCollection 2020.
6
Peptide-directed self-assembly of hydrogels.肽导向的水凝胶自组装
Acta Biomater. 2009 Mar;5(3):805-16. doi: 10.1016/j.actbio.2008.10.001. Epub 2008 Oct 14.
7
Genetically engineered block copolymers: influence of the length and structure of the coiled-coil blocks on hydrogel self-assembly.基因工程嵌段共聚物：卷曲螺旋嵌段的长度和结构对水凝胶自组装的影响
Pharm Res. 2008 Mar;25(3):674-82. doi: 10.1007/s11095-007-9343-z. Epub 2007 Aug 23.
8
Reversible hydrogels from self-assembling genetically engineered protein block copolymers.自组装基因工程蛋白嵌段共聚物形成的可逆水凝胶。
Biomacromolecules. 2005 May-Jun;6(3):1739-49. doi: 10.1021/bm050017f.
9
Smart self-assembled peptide-based hydrogels: Mechanism, design and biomedical applications.智能自组装肽基水凝胶：作用机制、设计与生物医学应用。
Colloids Surf B Biointerfaces. 2025 Apr 22;253:114704. doi: 10.1016/j.colsurfb.2025.114704.
10
Hydrogel-based ocular drug delivery systems for hydrophobic drugs.水凝胶基眼部药物传递系统用于疏水性药物。
Eur J Pharm Sci. 2020 Nov 1;154:105503. doi: 10.1016/j.ejps.2020.105503. Epub 2020 Aug 1.
引用本文的文献
1
Development of collagen-based hydrogel derived from allicin-silver nanoparticles for wound healing.用于伤口愈合的源自大蒜素-银纳米颗粒的胶原基水凝胶的研制。
Naturwissenschaften. 2025 Sep 8;112(5):67. doi: 10.1007/s00114-025-02017-8.
2
Advances in Conductive Biomaterials for Cardiac Tissue Engineering: Design, Fabrication, and Functional Integration.用于心脏组织工程的导电生物材料进展：设计、制造与功能整合
Polymers (Basel). 2025 Feb 26;17(5):620. doi: 10.3390/polym17050620.
3
Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network.通过超分子支撑网络改善聚乙二醇基水凝胶的生物活性和力学性能。
J Mater Chem B. 2025 Jan 22;13(4):1286-1295. doi: 10.1039/d4tb02002b.
4
Innovative theranostic hydrogels for targeted gastrointestinal cancer treatment.用于靶向胃肠道癌症治疗的创新治疗性水凝胶。
J Transl Med. 2024 Oct 27;22(1):970. doi: 10.1186/s12967-024-05749-9.
5
Hydrogel-based platforms for site-specific doxorubicin release in cancer therapy.基于水凝胶的平台用于癌症治疗中的阿霉素定点释放。
J Transl Med. 2024 Sep 30;22(1):879. doi: 10.1186/s12967-024-05490-3.
6
Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System.基于弹性蛋白衍生肽的水凝胶作为一种潜在的药物递送系统。
Gels. 2024 Aug 12;10(8):531. doi: 10.3390/gels10080531.
7
Frontier and hot topics in the application of hydrogel in the biomedical field: a bibliometric analysis based on CiteSpace.水凝胶在生物医学领域应用的前沿与热点：基于CiteSpace的文献计量分析
J Biol Eng. 2024 Jul 23;18(1):40. doi: 10.1186/s13036-024-00435-2.
8
Hydrophilic biomaterials: From crosslinked and self-assembled hydrogels to polymer-drug conjugates and drug-free macromolecular therapeutics.亲水性生物材料：从交联和自组装水凝胶到聚合物药物偶联物和无药物的高分子治疗剂。
J Control Release. 2024 Sep;373:1-22. doi: 10.1016/j.jconrel.2024.05.012. Epub 2024 May 17.
9
A Glucose-Responsive Cannula for Automated and Electronics-Free Insulin Delivery.一种葡萄糖响应式导管，用于实现自动化且无需电子设备的胰岛素输送。
Adv Mater. 2024 Jul;36(27):e2403594. doi: 10.1002/adma.202403594. Epub 2024 Apr 29.
10
Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review.再生水凝胶在皮肤创伤治疗中的研究进展：全面综述。
Int J Mol Sci. 2024 Mar 29;25(7):3849. doi: 10.3390/ijms25073849.
本文引用的文献
1
The Tumbleweed: towards a synthetic proteinmotor.风滚草：迈向合成蛋白质马达
HFSP J. 2009 Jun;3(3):204-12. doi: 10.2976/1.3111282. Epub 2009 Apr 28.
2
Self-assembled hydrogels from poly[N-(2-hydroxypropyl)methacrylamide] grafted with beta-sheet peptides.由接枝了β-折叠肽的聚[N-(2-羟丙基)甲基丙烯酰胺]自组装而成的水凝胶。
Biomacromolecules. 2009 Aug 10;10(8):2319-27. doi: 10.1021/bm9005084.
3
Stimuli-responsive properties of peptide-based copolymers studied via directional growth of self-assembled patterns on solid substrate.基于肽的共聚物的刺激响应特性研究：通过在固体基底上自组装图案的定向生长。
Biomacromolecules. 2009 Jul 13;10(7):1955-61. doi: 10.1021/bm900368c. Epub 2009 Jun 17.
4
Photodegradable hydrogels for dynamic tuning of physical and chemical properties.用于物理和化学性质动态调节的光降解水凝胶。
Science. 2009 Apr 3;324(5923):59-63. doi: 10.1126/science.1169494.
5
Characterizing ECM production by cells encapsulated in hydrogels.表征水凝胶包裹细胞产生细胞外基质的情况。
Methods Mol Biol. 2009;522:349-62. doi: 10.1007/978-1-59745-413-1_23.
6
PEG hydrogels for the controlled release of biomolecules in regenerative medicine.用于再生医学中生物分子控释的聚乙二醇水凝胶
Pharm Res. 2009 Mar;26(3):631-43. doi: 10.1007/s11095-008-9801-2. Epub 2008 Dec 18.
7
A periodic table of coiled-coil protein structures.卷曲螺旋蛋白结构的周期表。
J Mol Biol. 2009 Jan 23;385(3):726-32. doi: 10.1016/j.jmb.2008.11.028. Epub 2008 Nov 25.
8
Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.含有腺苷酸激酶的智能水凝胶：将底物识别转化为宏观运动。
J Am Chem Soc. 2008 Nov 26;130(47):15760-1. doi: 10.1021/ja805634x.
9
Peptide-directed self-assembly of hydrogels.肽导向的水凝胶自组装
Acta Biomater. 2009 Mar;5(3):805-16. doi: 10.1016/j.actbio.2008.10.001. Epub 2008 Oct 14.
10
Self-assembling diblock copolymers of poly[N-(2-hydroxypropyl)methacrylamide] and a beta-sheet peptide.聚[N-(2-羟丙基)甲基丙烯酰胺]与β-折叠肽的自组装二嵌段共聚物
Macromol Biosci. 2009 Jan 9;9(1):36-44. doi: 10.1002/mabi.200800193.
Zotero 插件