Black P M, Liszczak T, Kornblith P L
Acta Neuropathol. 1979 Apr 12;46(1-2):33-8. doi: 10.1007/BF00684801.
Cultured cells derived from a psammomatous meningioma were induced to from whorls in vitro by deprivation of nutrients. The ultrastructural features of desmosomes and junctional complexes were similar to sections from the surgical specimen; also prominent were 9-10 nm cytoplasmic filaments. Microelectrode recording of whorled cells showed a larger resting membrane potential than that of similar isolated meningioma cells in culture. Whorl formation seen in this tumor may be a result of relative nutritional deprivation and the need for metabolic cooperation among tumor cells.
从砂粒样脑膜瘤中获取的培养细胞，通过营养剥夺在体外被诱导形成涡旋。桥粒和连接复合体的超微结构特征与手术标本切片相似；同样显著的是9 - 10纳米的细胞质细丝。对涡旋状细胞的微电极记录显示，其静息膜电位比培养中类似的分离脑膜瘤细胞更大。在这种肿瘤中看到的涡旋形成可能是相对营养剥夺以及肿瘤细胞间代谢协作需求的结果。
