Weichselbaum R R, Liszczak T M, Phillips J P, Little J B, Epstein J, Kornblith P L
Cancer. 1977 Sep;40(3):1087-96. doi: 10.1002/1097-0142(197709)40:3<1087::aid-cncr2820400317>3.0.co;2-n.
Cultured cells from human medulloblastomas were demonstrated to have distinctive features and a "glial" potential from the morphological and ultrastructural parameters. The in vitro radiobiological survival curve parameters of cultured human medulloblastoma and non-malignant skin fibroblasts obtained under the same conditions of exponential growth were similar. In vitro conditions may underestimate the shoulder region of the survival curve. Since the shoulder region is the most important in clinical fractionated radiotherapy, multiple dose experiments might be useful in examining this portion of the survival curve more closely.
从人髓母细胞瘤培养的细胞经形态学和超微结构参数证实具有独特特征及“神经胶质”潜能。在指数生长的相同条件下获得的培养人髓母细胞瘤和非恶性皮肤成纤维细胞的体外放射生物学存活曲线参数相似。体外条件可能会低估存活曲线的肩区。由于肩区在临床分割放疗中最为重要，多剂量实验可能有助于更仔细地研究存活曲线的这一部分。
