Messmer K
Ann Anesthesiol Fr. 1979;20(9):823-8.
Limited hemodilution does not affect the respiratory function of the blood, neither in vitro nor in vivo. By virtue of the unchanged affinity of oxygen for hemoglobin and increase in nutritional flow, reduction in the O2 content of the blood is completely compensated. Tissue hypoxia does not develop as long as pulmonary and circulatory compensation is ensured. As a result, maintenance of a normal blood volume is an essential parameter. Information is not yet available concerning the relationship of O2 supplies in coronary disease. Coronary disease is presently considered to be a contra-indication since a marked reduction in the O2 content of the blood could restric coronary reserves and result in myocardial ischemia.
有限血液稀释对血液的呼吸功能无影响，无论在体外还是体内。由于氧与血红蛋白的亲和力不变且营养血流增加，血液中氧含量的降低可得到完全补偿。只要肺和循环代偿得以保证，就不会发生组织缺氧。因此，维持正常血容量是一个关键参数。关于冠心病中氧供应的关系目前尚无相关信息。由于血液中氧含量显著降低会限制冠状动脉储备并导致心肌缺血，冠心病目前被视为禁忌证。
