Nicolosi G L, Pugh D M, Dunn M
Am Heart J. 1979 Aug;98(2):171-5. doi: 10.1016/0002-8703(79)90218-7.
Eighty-seven patients (64 females and 23 males) with mitral stenosis were studied by M-mode echocardiography to assess the sensitivity and the specificity of the echocardiographic technique in the identification of valve calcification. The mitral valves were examined at operation, and the amounts of calcium were graded as heavy, light, or absent. We compared this with the amount of calcification assessed by radiographic, previously accepted echocardiographic, and newly derived echocardiographic criteria. In identifying the presence or absence of valve calcification, radiography was the least sensitive (53.7 per cent), but the most specific (90.9 per cent) technique, and has the highest predictive accuracy (90.6 per cent). Previously accepted echocardiographic criteria had the highest sensitivity (92.6 per cent), but the lowest specificity (12.1 per cent), and the lowest predictive accuracy (63.3 per cent). The newly derived echocardiographic parameter MT/ST (ratio between the maximal thickness of the left ventricular margin of the interventricular septum) was both sensitive (75.9 per cent) and specific (81.8 per cent) and also had a predictive accuracy (87.2 per cent) similar to that of radiographic techniques. The MT/ST ratio is demonstrated to be the most useful non-invasive method for assessing valve calcification in mitral stenosis.
87例二尖瓣狭窄患者（64例女性，23例男性）接受了M型超声心动图检查，以评估该超声心动图技术在识别瓣膜钙化方面的敏感性和特异性。术中对二尖瓣进行了检查，并将钙化量分为重度、轻度或无钙化。我们将其与通过X线摄影、先前公认的超声心动图以及新推导的超声心动图标准评估的钙化量进行了比较。在识别瓣膜钙化的有无方面，X线摄影是最不敏感的技术（53.7%），但特异性最高（90.9%），预测准确性也最高（90.6%）。先前公认的超声心动图标准敏感性最高（92.6%），但特异性最低（12.1%），预测准确性也最低（63.3%）。新推导的超声心动图参数MT/ST（室间隔左心室缘最大厚度之比）既敏感（75.9%）又特异（81.8%），预测准确性（87.2%）与X线摄影技术相似。MT/ST比值被证明是评估二尖瓣狭窄瓣膜钙化最有用的非侵入性方法。
