一种新型抗肿瘤药物：9-羟基玫瑰树碱。在DNA嵌入药物系列中合理设计抗癌药物的可能性。
A new antitumoral agent: 9-hydroxyellipticine. Possibility of a rational design of anticancerous drugs in the series of DNA intercalating drugs.
作者信息
Le Pecq J B, Gosse C, Paoletti C
出版信息
Proc Natl Acad Sci U S A. 1974 Dec;71(12):5078-82. doi: 10.1073/pnas.71.12.5078.
Abstract
The designing of DNA intercalating drugs with high DNA affinity in the series of ellipticine has led to a new antitumoral agent, 9-hydroxyellipticine, which has a high DNA affinity, a high activity on L 1210 mice leukemia, and a lack of toxicity at therapeutic dose. The possible correlations among chemical structure, DNA reactivity, and pharmacological activity of DNA intercalating drugs are discussed.
摘要
在玫瑰树碱系列中设计具有高DNA亲和力的DNA嵌入药物，已产生一种新的抗肿瘤药物9-羟基玫瑰树碱，它具有高DNA亲和力、对L1210小鼠白血病有高活性且在治疗剂量下无毒性。文中讨论了DNA嵌入药物的化学结构、DNA反应性和药理活性之间可能的相互关系。
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A new antitumoral agent: 9-hydroxyellipticine. Possibility of a rational design of anticancerous drugs in the series of DNA intercalating drugs.一种新型抗肿瘤药物：9-羟基玫瑰树碱。在DNA嵌入药物系列中合理设计抗癌药物的可能性。
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