van der Waaij D, Fekkerkerk-van der Wees J E, Heidt P J
J Hyg (Lond). 1974 Dec;73(3):409-14. doi: 10.1017/s0022172400042765.
The clearance of neomycin and kanamycin from the intestines after stopping oral supply has been determined in mice. Both antibiotics, although given in different doses, were excreted in essentially the same way; the clearance being a little faster than logarithmically in both cases. The importance of this observation with regard to isolation and the moment of reconventionalization is discussed.
在小鼠中测定了停止口服供应后新霉素和卡那霉素从肠道的清除情况。两种抗生素虽然给药剂量不同,但排泄方式基本相同;在两种情况下,清除速度都略快于对数清除。讨论了这一观察结果在隔离和重新常规化时机方面的重要性。