van der Waaij D, Berghuis-de Vries J M
J Hyg (Lond). 1972 Jun;70(2):335-42. doi: 10.1017/s0022172400022385.
After oral contamination of conventional mice with high doses of Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa the contaminant was recovered in abnormally high concentrations from the duodenum and caecum during the first few days. In this initial colonization phase, evidence of spread was obtained by culturing the cervical and mesenteric lymph nodes and spleen. Longer after contamination the intestinal concentration decreased to normal and spread stopped. In orally antibiotic-treated mice, the situation seen during the initial colonization phase in conventional mice occurred after a much lower oral contamination dose and persisted during the entire observation period of 2 weeks.
用高剂量的大肠杆菌、肺炎克雷伯菌或铜绿假单胞菌经口感染常规小鼠后，在最初几天内，十二指肠和盲肠中污染物的回收浓度异常高。在这个初始定植阶段，通过培养颈部和肠系膜淋巴结以及脾脏获得了扩散的证据。污染后较长时间，肠道浓度降至正常，扩散停止。在经口服抗生素治疗的小鼠中，常规小鼠在初始定植阶段出现的情况在口服污染剂量低得多的情况下就会出现，并且在整个2周的观察期内持续存在。
