Seko Y, Miura T, Takahashi M, Koyama T
Acta Pharmacol Toxicol (Copenh). 1981 Oct;49(4):259-65. doi: 10.1111/j.1600-0773.1981.tb00903.x.
The role of intestinal flora in the decomposition and faecal excretion of methyl mercury was studied in mice treated with antibiotics. The antibiotics, neomycin sulfate and chloramphenicol, were given to mice in drinking water for six days before intraperitoneal administration of methyl mercuric chloride (MMC), and intestinal microorganisms were thereby reduced. Inorganic and organic mercury were determined separately for faeces, intestinal contents and organs. On the fourth day after the mercury administration, the percentage ratios of inorganic mercury to total mercury in the contents of the caecum and large intestine were less in the mice treated with antibiotics, at 37% and 39%, respectively, than in the control mice (66% and 65%, respectively). Administration of the antibiotics reduced the excretion of inorganic mercury in the faeces to 26% of that of control mice and also reduced the excretion of total mercury to 60%. Reduction of intestinal microorganisms by the antibiotics was assumed to have caused the reduced decomposition of methyl mercury in the caecal contents and the reduced excretion of total mercury in the faeces.
在使用抗生素处理的小鼠中研究了肠道菌群在甲基汞分解和粪便排泄中的作用。在腹腔注射氯化甲基汞（MMC）前六天，将抗生素硫酸新霉素和氯霉素加入小鼠饮用水中，从而减少肠道微生物。分别测定粪便、肠道内容物和器官中的无机汞和有机汞。在给予汞后的第四天，用抗生素处理的小鼠盲肠和大肠内容物中无机汞占总汞的百分比分别为37%和39%，低于对照小鼠（分别为66%和65%）。给予抗生素使粪便中无机汞的排泄量降至对照小鼠的26%，也使总汞的排泄量降至60%。据推测，抗生素导致肠道微生物减少，从而使盲肠内容物中甲基汞的分解减少，粪便中总汞的排泄减少。
