Fiala M, Kaushik V, Chatterjee S, Lluncor E, Huang J
Am J Med Sci. 1979 May-Jun;277(3):305-9. doi: 10.1097/00000441-197905000-00009.
Ten patients with a mean age of 34.1 years with infective endocarditis (55% of cases due to Staphylococcus aureus) were treated with cephradine. The peak serum levels of cephradine (8-42 microgram/ml) were 3- to 17-fold higher than the minimum inhibitory concentrations of cephradine against pathogenic strains of S aureus (1.2-4 microgram/ml). Patients treated with cephradine became afebrile in 2 to 13 days of therapy, and their white blood cell count returned to a normal level in 3 to 30 days. Cephradine therapy was well tolerated without any incidence of phlebitis. The drug could be administered by three different routes. Cephradine is a useful cephalosporin for treatment of nonenterococcal gram-positive endocarditis in young heroin addicts.
10例平均年龄34.1岁的感染性心内膜炎患者（55%的病例由金黄色葡萄球菌引起）接受了头孢拉定治疗。头孢拉定的血清峰值水平（8 - 42微克/毫升）比其对金黄色葡萄球菌致病菌株的最低抑菌浓度（1.2 - 4微克/毫升）高3至17倍。接受头孢拉定治疗的患者在治疗2至13天内退热，白细胞计数在3至30天内恢复正常水平。头孢拉定治疗耐受性良好，未发生静脉炎。该药物可通过三种不同途径给药。头孢拉定是治疗年轻海洛因成瘾者非肠球菌革兰氏阳性心内膜炎的一种有效头孢菌素。
