Cline D L
Am J Obstet Gynecol. 1979 Jun 15;134(4):438-44. doi: 10.1016/s0002-9378(16)33086-1.
Patients with different types of luteal phase defects were studied with the use of the radioimmunoassay for the beta subunit of human chorionic gonadotropin (hCG) to determine if unsuspected subclinical pregnancies were more common in a particular type of defect. A type I luteal phase defect is always characterized by a chronologic lag in endometrial development when repeatedly studied with timed endometrial biopsies. A type II luteal phase defect is always characterized by an in phase endometrium when repeatedly studied by timed endometrial biopsies but always has less than a 14 day luteal span. All blood samples were drawn at least 7 days after ovulation/conception. In 22 cycles in which patients had a type I luteal phase defect, no subclinical pregnancies were detected. In 18 cycles in which a type II luteal phase defect was present, 12 instances of unsuspected subclinical pregnancy were detected and all ended in spontaneous abortion. This study shows that unsuspected subclinical pregnancies ending in abortion do occur and are quite commonly associated with the type II luteal phase defect.
我们使用人绒毛膜促性腺激素（hCG）β亚基的放射免疫测定法，对不同类型黄体期缺陷的患者进行了研究，以确定在某一特定类型的缺陷中，未被察觉的亚临床妊娠是否更为常见。I型黄体期缺陷的特征在于，通过定时子宫内膜活检反复研究时，子宫内膜发育存在时间上的滞后。II型黄体期缺陷的特征在于，通过定时子宫内膜活检反复研究时，子宫内膜呈同步状态，但黄体期总是少于14天。所有血样均在排卵/受孕后至少7天采集。在22个患者存在I型黄体期缺陷的周期中，未检测到亚临床妊娠。在18个存在II型黄体期缺陷的周期中，检测到12例未被察觉的亚临床妊娠，且所有妊娠均以自然流产告终。这项研究表明，以流产告终的未被察觉的亚临床妊娠确实会发生，并且相当常见于II型黄体期缺陷。
