Onoue T, Nagata Y, Kusuda M
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Aug;33(8):1255-8.
Serum hCG was measured by specific beta-hCG radioimmunoassay during the late luteal phase in 58 infertile women recording the basal body temperature. As control, serum hCG was also measured during the 5th to 17th day after the basal body temperature shift in 18 normal pregnancy. In all normal pregnancy cases serum hCG was detected after the 9th day from basal temperature shift. Serum hCG was detected during the late luteal phase in 6 cases, including 2 cases succeeded in pregnancy in corresponding cycle, out of 58 infertile women. In spite of the hCG detection, the hyperthermic phase on BBT chart was not significantly prolonged in remaining 4 cases, in which the next menses took place as usual. Thus, so called subclinical abortion was suspected in these 4 cycles. This result suggests subclinical abortion might occur in infertile women. When hCG is detected during the late luteal phase, intensive treatment for the defective luteal function may salvage the endangered pregnancy. Since the incidence of hCG detection in this study was rather smaller than the previous reports, the major portion of causes of infertility might exist earlier or around the time of implantation of fertilized ovum.
采用特异性β - hCG放射免疫分析法，在黄体晚期对58名记录基础体温的不孕妇女测定血清hCG。作为对照，在18例正常妊娠者基础体温转变后的第5至17天也测定血清hCG。在所有正常妊娠病例中，从基础体温转变后第9天开始检测到血清hCG。58名不孕妇女中，有6例在黄体晚期检测到血清hCG，其中2例在相应周期成功妊娠。尽管检测到hCG，但其余4例基础体温图上的高温期并未显著延长，下次月经如常来潮。因此，怀疑这4个周期发生了所谓的亚临床流产。该结果提示亚临床流产可能在不孕妇女中发生。当在黄体晚期检测到hCG时，针对黄体功能不全的强化治疗可能挽救濒危妊娠。由于本研究中hCG检测的发生率比先前报道的要低，不孕的主要原因可能在更早的时候或受精卵着床前后就已存在。
