Hall R J, Creamer B
Gut. 1974 Nov;15(11):858-61. doi: 10.1136/gut.15.11.858.
Six patients with hyperphagia (ingestion of 5-11 000 Kcals/day) associated with severe malabsorption and steatorrhoea are described. The cause of the malabsorption was coeliac disease in three patients, Crohn's disease with ileal resection in two, and carcinoma of the pancreas in one patient. There was no evidence of neurological or endocrine disease (apart from mild diabetes mellitus in the patient with carcinoma of the pancreas) but three patients suffered from severe depression. This association may be commoner than previously realized and be revealed in patients with steatorrhoea of unexplained severity by careful dietary assessment. Its detection has therapeutic implications since restriction of caloric and fat intake decreased steatorrhoea without weight loss in several of the patients described.
本文描述了6例食欲亢进（每日摄入热量5000 - 11000千卡）并伴有严重吸收不良和脂肪泻的患者。其中3例患者吸收不良的病因是乳糜泻，2例是克罗恩病伴回肠切除术，1例是胰腺癌。没有神经或内分泌疾病的证据（除了胰腺癌患者伴有轻度糖尿病），但有3例患者患有严重抑郁症。这种关联可能比之前认为的更为常见，通过仔细的饮食评估，可能在原因不明的严重脂肪泻患者中发现。其发现具有治疗意义，因为对本文所述的几名患者限制热量和脂肪摄入后，脂肪泻减轻但体重未减轻。
