Woodruff K H, Leith J T, Powers-Risius P, Havens V, Lyman J T, Howard J, Tobias C A
Am J Pathol. 1979 Jun;95(3):765-74.
Important new modalities for cancer therapy are being developed, and one of the most promising is heavy charged particle irradiation. We are currently assessing the effects of 375-MeV/nucleon neon irradiation in the plateau region of ionization compared to 230KVp X-rays on the whole thorax of hamsters. Single dose levels for neon irradiation ranged from 150-1000 rad. Dose levels for X-irradiation ranged from 225-1500 rad. The animals were followed for 1 year after irradiation, and the most useful results emerged, using morphometric methods. One year after irradiation, pulmonary parenchyma and nonparenchyma appear morphometrically unchanged. However, the volume density of pulmonary septums, septal cells, all tissue, connective tissue, and alveolar Type II cells was increased while the volume densities of alveoli, empty alveolar space, and capillary lumens were diminished. Most of these changes were dose dependent not clearly demonstrable until a year after irradiation. The relative biologic effect of neon compared to X-irradiation using this techniques is 1.6-1.8.
癌症治疗的重要新方法正在不断发展，其中最有前景的方法之一是重带电粒子辐射。我们目前正在评估与230KVp X射线相比，375兆电子伏特/核子的氖辐射在电离平台区域对仓鼠整个胸部的影响。氖辐射的单剂量水平范围为150 - 1000拉德。X射线辐射的剂量水平范围为225 - 1500拉德。照射后对动物进行了1年的跟踪观察，并采用形态测量方法得出了最有用的结果。照射1年后，肺实质和非实质在形态测量上没有变化。然而，肺间隔、间隔细胞、所有组织、结缔组织和肺泡II型细胞的体积密度增加，而肺泡、空肺泡空间和毛细血管腔的体积密度减小。这些变化大多是剂量依赖性的，直到照射1年后才明显显现。使用该技术，氖与X射线辐射相比的相对生物效应为1.6 - 1.8。
