Ewert A, Corredor A, Lightner L, D'Alessandro A
Am J Trop Med Hyg. 1979 May;28(3):486-90. doi: 10.4269/ajtmh.1979.28.486.
This study is a follow-up of a 1965 investigation of the only known focus of Onchocerca volvulus in Colombia. In the first phase of the current study, 254 persons were examined. Of the 19 individuals found to be infected with O. volvulus, the youngest was a 16-year-old male. Among those included in the 1965 study, 22 were examined again for microfilariae. Two were positive in both studies, 4 were positive in 1965 but negative in 1977 and the remaining 16 were negative on both occasions. The prevalence of infection, based on identification of microfilariae in skin snips, was lower in the current study (7.5%) than the 15.1% recorded 12 years earlier. However, a 50% response to the Mazzotti test (administration of oral diethylcarbamazine) among a limited number of people upstream from the previously identified endemic area suggests that infection with O. volvulus may be quite widespread.
本研究是对1965年在哥伦比亚对盘尾丝虫唯一已知疫源地进行的一项调查的后续研究。在本研究的第一阶段，对254人进行了检查。在发现感染盘尾丝虫的19人中，最年轻的是一名16岁男性。在1965年研究纳入的人员中，对22人再次进行了微丝蚴检查。两人在两项研究中均呈阳性，4人在1965年呈阳性但在1977年呈阴性，其余16人在两次检查中均呈阴性。基于皮肤切片中微丝蚴的鉴定，本次研究中的感染率（7.5%）低于12年前记录的15.1%。然而，在先前确定的流行区上游有限数量的人群中，对马佐蒂试验（口服乙胺嗪）有50%的反应表明，盘尾丝虫感染可能相当普遍。
