McKusick K A, Wagner H N, Soin J S, Benjamin J J, Cooper M, Ball W C
Scand J Respir Dis Suppl. 1974;85:51-63.
Radioisotopic regional lung function measurements using both 99mTc-labeled albumin microspheres and inhaled 133Xe were compared to measurements of total lung function in a population of 30 participants in an epidemiological study of the causative factors of obstructive pulmonary disease. Five of the 8 asymptomatic subjects who had no evidence of obstruction by the tests of total function had abnormal regional lung function measurements. The closing volume was abnormal in three of these five, suggesting the presence of small airways disease. Regional lung function was abnormal in all subjects who were symptomatic, who had a FEV1/FVC less than 75%, or who had an elevated closing volume or residual volume. The data indicate that the measurement of regional lung function may be a highly sensitive test for the early diagnosis of chronic obstructive pulmonary disease.
在一项关于阻塞性肺疾病致病因素的流行病学研究中，对30名参与者使用99mTc标记的白蛋白微球和吸入的133Xe进行放射性同位素区域肺功能测量，并与总肺功能测量结果进行比较。在8名无症状受试者中，有5名通过总功能测试未发现阻塞证据，但区域肺功能测量结果异常。这5名受试者中有3名闭合气量异常，提示存在小气道疾病。所有有症状、FEV1/FVC小于75%、闭合气量或残气量升高的受试者区域肺功能均异常。数据表明，区域肺功能测量可能是慢性阻塞性肺疾病早期诊断的高度敏感测试。
