细胞松弛素B：对黑素细胞内微丝及黑素颗粒移动的影响
Cytochalasin B: effects on microfilaments and movement of melanin granules within melanocytes.
作者信息
McGuire J, Moellmann G
出版信息
Science. 1972 Feb 11;175(4022):642-4. doi: 10.1126/science.175.4022.642.
PMID:4536685
Abstract
The intracellular translocation of melanin granules within both epidermal and dermal melanocytes of Rana pipiens is influenced by cytochalasin B. Cytochalasin B prevents dispersion of pigment granules by melanocytestimulating hormone (MSH) and causes centripetal movement of pigment granules that have been dispersed by MSH. Microfilaments are abundant in the dendritic processes of epidermal melanocytes in which pigment granules have been dispersed by MSH. Microfilaments are dramatically reduced in number in the processes of melanocytes that have been lightened by cytochalasin B. These observations suggest that microfilaments mediate dispersion of pigment granules.
摘要
细胞松弛素B会影响豹蛙表皮和真皮黑素细胞内黑素颗粒的细胞内转运。细胞松弛素B可阻止黑素细胞刺激激素（MSH）使色素颗粒分散，并导致已被MSH分散的色素颗粒向心移动。在表皮黑素细胞的树突状突起中微丝丰富，其中色素颗粒已被MSH分散。在被细胞松弛素B变淡的黑素细胞的突起中，微丝数量显著减少。这些观察结果表明微丝介导色素颗粒的分散。
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