Rosato F E, Walburgh E E, Langley J, Cox A D
Am Surg. 1979 May;45(5):273-80.
We have presented our experience in light of current practice in the management of malignant melanoma. Central to considerations of adequate management is the question of precise definition of the extent of the disease as determined by histologic evaluation, determination of the depth of penetration and assessment of the extent of spread. Wide surgical excision remains the most important consideration with perfusion therapy, in our view playing a key role in the management of extremity melanoma. Encouraging data for adjuvant immunotherapy continues to unfold. We present here a rational approach to diagnosis and management of malignant melanoma.
我们根据目前恶性黑色素瘤的管理实践介绍了我们的经验。充分管理的核心考虑因素是通过组织学评估确定疾病范围的精确定义、浸润深度的测定以及扩散程度的评估。广泛的手术切除仍然是最重要的考虑因素，而灌注疗法在我们看来在四肢黑色素瘤的管理中起着关键作用。辅助免疫疗法的鼓舞人心的数据不断涌现。我们在此提出一种恶性黑色素瘤诊断和管理的合理方法。
